Research & Development Services

Lonza’s R&D Activities

To achieve robust and efficient process qualification for scale up, we make extensive use of modern tools such as automated workstations for screening of various process parameters, statistical software, and reaction calorimetry. Quality control and quality assurance departments support Lonza’s development activities. With a clear focus on minimizing the number of unit operations of chemical and microbial processes, we support cost competitive manufacturing on an industrial scale. Lonza offers a broad spectrum of research and development services using state-of-the-art chemical and microbial technologies. Depending on regulatory and customer needs we concentrate on:

Feasibility studies which include: development of innovative processes; 2nd generation processes: e.g. asymmetric hydrogenation, alternative biotransformation routes; timeframe: 1–3 months
Small scale quantities delivered in a timely manner (10–100 kg, 3–10 chemical steps; APIs), timeframe: 2–3 months
Process development for and production of launch quantities (100 kg – 5 tons), full regulatory support, validated processes; APIs, HAPIs; timeframe: 3–6 months
Support of direct technology transfers from clients to our industrial plants; timeframe: 1–3 months
Continuous process optimization throughout the product life cycle

Our capabilities include:

Expertise in Hazardous and Highly Reactive Chemicals HCN, ClCN, chlorosulfonyl isocyanate, SOCl2, Cl2 (gas/liquid), ketene, diketene, phosgene (cGMP), CO, acetylene, ethylene Organometallic Reactions Grignard, organolithium, sodium in liquid NH3, organozinc reactions, Heck reactions Reductions Catalytic hydrogenation (homogeneous and heterogeneous), metal hydrides (NaBH4, LiAIH4), raney nickel Oxidations With ozone (batch and continuous), peroxides, oxygen/air, nitric acid, ammoxidation Reactions under special conditions Low-temperature reactions (-90°C) High-temperature reactions (+250°C) High-pressure reactions (10–100 bar) Asymmetric reactions Transition metal catalysts (hydrogenation, oxidation, Heck/Aldol), biocatalysts, racemate separation, use of chiral building blocks Highly Active Pharmaceutical Ingredients (HAPIs) Special laboratory (class 100 000) for development, small- and large-scale production. Learn more Peptides Lonza offers the production of tailored peptides and from gram scale up to several hundred kilogram quantities. Learn more Microbial Fermentation and Biotransformations Lonza offers custom microbial fermentation and biotransformation services to supply intermediates and biologically active products. Learn more


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Lonza’s R&D Activities